AN UPDATE ON LOW DOSE COMPUTED TOMOGRAPHY FOR LUNG CANCER SCREENING
Abstract
Since the publication of the National Lung Screening Trial (NLST) showing a mortality reduction with use of low dose computed tomography (LDCT) there has been considerable interest about the use of this modality to screen for lung cancer. This article reviews the NLST and current evidence behind screening for lung cancer in smokers. It also attempts to look at different lung cancer risk models to help better define the ideal target population and lastly touches on the cost-effectiveness of LDCT screening in patients at high risk of lung cancer.
References
Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136:E359‑86.
Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Allen C, et al. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32
cancer groups, 1990 to 2015: A systematic analysis for the global burden of disease study. JAMA Oncol 2017;3:524-48.
Tanoue LT, Tanner NT, Gould MK, et al. Lung cancer screening. Am J Respir Crit Care Med 2015;191:19-33.
Oken MM, Hocking WG, Kvale PA, et al. Screening by chest radiograph and lung cancer mortality: The prostate, lung, colorectal, and ovarian (PLCO) randomized trial. JAMA 2011;306:1865-73.
Swensen SJ, Jett JR, Hartman TE, et al. CT screening for lung cancer: Five-year prospective experience. Radiology 2005; 235:259-65.
Henschke CI, McCauley DI, Yankelevitz DF, et al. Early lung cancer action project: Overall design and findings from baseline screening. Lancet 1999;354:99-105.
Henschke CI, Naidich DP, Yankelevitz DF, et al. Early lung cancer action project: Initial findings on repeat screenings. Cancer 2001;92:153-9.
Mulshine JL, Sullivan DC. Clinical practice. Lung cancer screening. N Engl J Med 2005;352:2714-20.
National Lung Screening Trial Research Team, Aberle DR,
Adams AM, et al. Reduced lung-cancer mortality with low dose computed tomographic screening. N Engl J Med 2011; 365:395-409.
van Iersel CA, de Koning HJ, Draisma G, et al. Risk based selection from the general population in a screening trial: Selection criteria, recruitment and power for the dutch-belgian randomised lung cancer multi-slice CT screening trial (NELSON). Int J Cancer 2007;120:868-74.
Moyer VA, U.S. Preventive Services Task Force. Screening for lung cancer: U.S. Preventive services task force recommendation statement. Ann Intern Med 2014;160:330‑8.
Kovalchik SA, Tammemagi M, Berg CD, et al. Targeting of low-dose CT screening according to the risk of lung-cancer death. N Engl J Med 2013;369:245-54.
Tammemägi MC, Katki HA, Hocking WG, et al. Selection criteria for lung-cancer screening. N Engl J Med 2013; 368:728-36.
Sanchez-Salcedo P, Wilson DO, de-Torres JP, et al. Improving
selection criteria for lung cancer screening. The potential role of emphysema. Am J Respir Crit Care Med 2015;191:924-31.
Pinsky PF, Berg CD. Applying the national lung screening trial eligibility criteria to the US population: What percent of the population and of incident lung cancers would be covered? J Med Screen 2012;19:154-6.
Sagawa M, Sugawara T, Ishibashi N, et al. Efficacy of low-dose computed tomography screening for lung cancer: The currentstate of evidence of mortality reduction. Surg Today 2017;47:783-8.
Sagawa M, Nakayama T, Tanaka M, et al. A randomized controlled trial on the efficacy of thoracic CT screening for lung cancer in non-smokers and smokers of <30 pack-years aged 50-64 years (JECS study): Research design. Jpn J Clin Oncol 2012;42:1219-21.
Black WC, Gareen IF, Soneji SS, et al. Cost-effectiveness of CT screening in the national lung screening trial. N Engl J Med 2014;371:1793-802.
Raymakers AJ, Mayo J, Lam S, et al. Cost-effectiveness analyses of lung cancer screening strategies using low-dose computed tomography: A systematic review. Appl Health Econ Health Policy 2016;14:409-18.
Puggina A, Broumas A, Ricciardi W, et al. Costeffectiveness
of screening for lung cancer with low-dose computed tomography: A systematic literature review. Eur J Public Health 2016;26:168-75.
van der Aalst CM, Haaf KT, de Koning HJ. Lung cancer screening: Latest developments and unanswered questions. Lancet Respir Med 2016;4:749-61.
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